The Office star Carell plays the role of Gru
Despicable Me 2 has topped the US box office chart, beating Johnny Depp's The Lone Ranger to the top spot.
The Universal Pictures animation sequel made $82.5m (£55.4m) over the weekend according to early estimates.Disney's Lone Ranger, starring Depp as Tonto in a reboot of the radio and TV series, took just $29.5m (£19.8m).
Dave Hollis, Disney's head of distribution, said: "We thought it would appeal to a broader audience than it did."
The film, which has received poor reviews from critics, reportedly cost at least $225m (£151m) to make.
The majority of the film's audience in its debut weekend were over 25 years of age.
US box office top five
- Despicable Me 2 - $82.5m
- The Lone Ranger - $29.4m
- The Heat - $25m
- Monsters University - $19.6m
- World War Z - $18.2m
"You think you have everything in place," said Hollis.
"Even when you have all the ingredients for what you think
will be a four-quadrant 'everybody' picture, sometimes it doesn't work
out that way."Despicable Me 2 stars Steve Carell as a villain who becomes a stay-at-home dad.
The family film features the now famous little yellow creatures called minions.
Nikki Rocco, head of distribution, said a third Despicable Me film was in the pipeline.
"The minions steal everybody's heart," said Rocco. "It's a great time of year to release a family film with broad appeal."
Last week's number one, female cop comedy The Heat starring Sandra Bullock and Melissa McCarthy, fell to third place taking $25m (£16.7m).
Monsters University and Brad Pitt's World War Z rounded out the top five
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